On the use of temporal filtering for mitigating galactic synchrotron calibration bias in 21 cm reionization observations

Precision antenna calibration is required for mitigating the impact of foreground contamination in 21 cm cosmological radio surveys. One widely studied source of error is the effect of missing point sources in the calibration sky model; however, poorly understood diffuse galactic emission also creates a calibration bias that can complicate the clean separation of foregrounds from the 21 cm signal. In this work, we present a technique for suppressing this bias with temporal filtering of radio interferometric visibilities observed in a drift-scan mode. We demonstrate this technique on mock simulations of the Hydrogen Epoch of Reionization Array (HERA) experiment. Inspecting the recovered calibration solutions, we find that our technique reduces spurious errors by over an order of magnitude. This improved accuracy approaches the required accuracy needed to make a fiducial detection of the 21 cm signal with HERA, but is dependent on a number of external factors that we discuss. We also explore different types of temporal filtering techniques and discuss their relative performance and tradeoffs

The Impact of Beam Variations on Power Spectrum Estimation for 21 cm Cosmology II: Mitigation of Foreground Systematics for HERA

One key challenge in detecting 21 cm cosmological signal at z > 6 is to separate the cosmological signal from foreground emission. This can be studied in a power spectrum space where the foreground is confined to low delay modes whereas the cosmological signal can spread out to high delay modes. When there is a calibration error, however, chromaticity of gain errors propagates to the power spectrum estimate and contaminates the modes for cosmological detection. The Hydrogen Epoch of Reionization Array (HERA) employs a high-precision calibration scheme using redundancy in measurements. In this study, we focus on the gain errors induced by nonredundancies arising from feed offset relative to the HERA's 14 meter parabolic dish element, and investigate how to mitigate the chromatic gain errors using three different methods: restricting baseline lengths for calibration, smoothing the antenna gains, and applying a temporal filter prior to calibration. With 2 cm/2 degree perturbations for translation/tilting motions, a level achievable under normal HERA operating conditions, the combination of the baseline cut and temporal filtering indicates that the spurious gain feature due to nonredundancies is significantly reduced, and the power spectrum recovers the clean foreground-free region. We found that the mitigation technique works even for large feed motions but in order to keep a stable calibration process, the feed positions need to be constrained to 2 cm for translation motions and 2 degree for tilting offset relative to the dish's vertex.Comment: Accepted for publication in Ap

Hydrogen Epoch of Reionization Array (HERA)

The Hydrogen Epoch of Reionization Array (HERA) is a staged experiment to measure 21 cm emission from the primordial intergalactic medium (IGM) throughout cosmic reionization ($z=6-12$), and to explore earlier epochs of our Cosmic Dawn ($z\sim30$). During these epochs, early stars and black holes heated and ionized the IGM, introducing fluctuations in 21 cm emission. HERA is designed to characterize the evolution of the 21 cm power spectrum to constrain the timing and morphology of reionization, the properties of the first galaxies, the evolution of large-scale structure, and the early sources of heating. The full HERA instrument will be a 350-element interferometer in South Africa consisting of 14-m parabolic dishes observing from 50 to 250 MHz. Currently, 19 dishes have been deployed on site and the next 18 are under construction. HERA has been designated as an SKA Precursor instrument. In this paper, we summarize HERA's scientific context and provide forecasts for its key science results. After reviewing the current state of the art in foreground mitigation, we use the delay-spectrum technique to motivate high-level performance requirements for the HERA instrument. Next, we present the HERA instrument design, along with the subsystem specifications that ensure that HERA meets its performance requirements. Finally, we summarize the schedule and status of the project. We conclude by suggesting that, given the realities of foreground contamination, current-generation 21 cm instruments are approaching their sensitivity limits. HERA is designed to bring both the sensitivity and the precision to deliver its primary science on the basis of proven foreground filtering techniques, while developing new subtraction techniques to unlock new capabilities. The result will be a major step toward realizing the widely recognized scientific potential of 21 cm cosmology.Comment: 26 pages, 24 figures, 2 table

Efficacy of trabectedin in metastatic solitary fibrous tumor

Solitary fibrous tumor is a rare tumor type and has an unpredictable course. Local recurrence rate varies between 9 and 19%, and rate of metastatic involvement between 0 and 36 %. It is characterized by a typical architecture and immuno-histochemistry tests. The most important prognostic factor is the complete resection of primary tumor. Treatment of recurrences is not clearly established. If a solitary fibrous tumor is too advanced to allow surgical resection, radiotherapy and chemotherapy may be used. The most often used drugs are doxorubicine and\or ifosfamide. We report the case of man with metastatic solitary fibrous tumor treated with trabectedin, administered at a dose of 1.5 mg/m² every 3 weeks. After 3 cycles, metastases had significantly decreased. Recurrence of the disease was demonstrated 8 months after the start of trabectedin. This case shows that trabectedin is a possible treatment option